Some people are mosquito magnets, and a new study reveals why

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Are you one of those people who are considered real mosquito “magnets”? For a long time this specificity – admittedly not enviable – was misunderstood. Researchers from the Laboratory of Neurogenetics and Behavior at Rockefeller University have finally identified what makes a person irresistible to these insects: the presence of certain fatty acids on the skin. This discovery may lead to the development of more effective repellent products.

Mosquitoes are irreversibly attracted to the CO2 we exhale, our heat and our body odor. But some people, unfortunately for them, are even more purposeful than others. According to some popular beliefs, blood type, blood sugar or certain foods consumed could more or less attract these pests. However, scientific evidence to support any of these hypotheses is lacking. Scientists have set out to explore one of the most plausible theories that could explain the greater or lesser attraction of mosquitoes to a human body: variations in odors associated with skin microbiota.

First, they tested the effect of different human skin odors on mosquitoes to identify which people were the most attractive and the least attractive to these insects. A chemical analysis of body odor showed that the most attractive people produce significantly more carboxylic acids in their skin vapors. ” There is a very, very strong correlation between having large amounts of these fatty acids on the skin and being a mosquito magnet. says Leslie Vosshall, who led the study. It appears that even olfactory-deficient mosquitoes manage to distinguish these primary targets from the others.

An attractive force due to carboxylic acids

The researchers asked 64 volunteers to wear nylon sleeves on their forearms for six hours a day, on consecutive days, to collect odor samples of human skin. Over the course of the next three years of study, the team tested the nylon sleeves’ attraction to each other via all possible pairings. To do this, she used a two-choice olfactometer: a Plexiglas chamber divided into two tubes, each ending in a box with a sleeve.

Mosquitoes of the species Aedes aegypti – the main vectors of dengue fever, Zika virus infection, chikungunya and yellow fever – were placed in the main chamber and then the researchers observed the behavior of the insects. In total, they performed more than 2330 behavioral tests. Test subjects were deidentified so experimenters did not know which participant wore which nylon.

(A) Schematic of two-choice olfactometric test. Percent attraction of human forearms (B) or a piece of nylon (CD) worn by one of the subjects compared to a control piece of nylon. © ME De Obaldia et al.

One of the participants, here “subject 33”, stood out in particular: he was found to be four times more attractive to mosquitoes than the second most attractive participant and 100 times more attractive than the least attractive (identified as “Subject 19”). It’s quite simple: in every test involving a sleeve worn by subject 33, mosquitoes gathered around him. The researchers then ranked the participants from most attractive to least attractive, and then analyzed their olfactory profiles to determine what could explain this large difference.

This is how they identified about fifty molecular compounds present in greater numbers in the sebum of participants with strong attraction. In particular, they found that the “mosquito magnets” produced carboxylic acids at much higher levels than the others.

A property that lasts a lifetime

These acids are naturally present in sebum; they help protect and moisturize the skin, and the amount of acids produced varies from person to person. However, the skin maintains a constant level of carboxylic acids over time, so body odor also remains constant. In fact, subject 33 remained the most attractive even after several months.

Some subjects participated in the study for several years, and we found that if they were a mosquito magnet, they remained one. Many things might have changed in the subject or in his behavior during this period, but it was a very stable characteristic of the person. », emphasizes Maria Elena De Obaldia, co-author of the study. In other words, no matter what changes are made – in food or skin care products – a mosquito magnet remains a mosquito magnet for life.

Mosquitoes detect human odors with two sets of olfactory receptors: Orco and IR receptors. Following their discovery, the researchers therefore created mutant mosquitoes, devoid of one or both receptors, to assess their ability to detect human odors. Mosquitoes without Orco receptors remained strongly attracted to humans and remained able to discriminate between highly attractive and less attractive individuals. Mosquitoes without IR receptors lost their attraction to humans to varying degrees, but still retained the ability to distinguish individuals.

Despite the elimination of smell receptors (by genetic modification), mosquitoes still manage to spot the most attractive individuals. © ME De Obaldia et al.

These results disappointed the team, which hoped to find a way to distinguish the most attractive subjects from the others in order to develop a more effective deterrent. However, they are consistent with another study previously conducted by Vosshall and colleagues, which showed the remarkable robustness of mosquitoes; their neurons co-express multiple chemosensory receptors, giving the system almost unstoppable redundancy.

According to Vosshall, one potential clue is to manipulate the skin’s microbiome, for example by coating the skin of a highly attractive person with skin bacteria from an unattractive person, to alter its olfactory profile. However, the team has not yet put this experience into practice.

Source: ME From Obaldia et al., Cell

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